FMOC-L-2-CARBAMOYLPHE CAS 959583-60-9

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Fmoc-L-2-CarbamoylPhe (CAS: 959583-60-9) is a precision designed functionalized non natural amino acid derivative that has demonstrated unique application value in modern pharmaceutical chemistry and peptide engineering. Its molecular structure is modified with an amino formyl group at the second position of the benzene ring in the classical phenylalanine skeleton, while the α - amino group is protected by the Fmoc group standard. This ingenious design makes it a key structural unit for enhancing the targeting and stability of peptide drugs.
The core advantage of this compound lies in its unique side chain functionalization properties. The amino formyl group on the benzene ring not only significantly enhances the polarity of residues, but also provides additional hydrogen bond donor and acceptor capabilities, enabling it to form a more diverse molecular interaction network with biological targets. This characteristic makes it an ideal tool for precise regulation of peptide receptor binding patterns in solid-phase peptide synthesis, particularly suitable for optimizing the affinity and selectivity of therapeutic peptides.
In the field of innovative drug development, the application of Fmoc-L-2-CarbamoylPhe is particularly critical. As a pharmaceutical grade protected amino acid, it is widely used to construct novel peptide lead compounds with enhanced properties. By strategically embedding the non natural residue into peptide sequences, researchers can effectively improve the metabolic stability, solubility, and membrane permeability of candidate molecules, while fine-tuning their interaction patterns with disease targets through precise side chain engineering. These characteristics demonstrate broad application prospects in the development of innovative therapies targeting protein-protein interactions, particularly in the fields of tumor therapy and metabolic diseases, providing new molecular solutions to overcome the limitations of traditional peptide drugs.

 

 

 

    

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