D-Pen-OH CAS 52-67-5

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D-Pen-OH is a pharmaceutical intermediate with unique pharmacological activity and important synthetic value. As a D-configured penicillin, it is not only a key building block in the production process of various antimicrobial active ingredients (APIs), but also plays a dual role in the field of therapy and modern drug development due to its unique molecular structure.
In clinical treatment, the core value of D-penicillamine lies in its excellent metal chelation ability and immune regulatory function. It is approved for the treatment of Wilson's disease (a hereditary copper metabolism disorder) by strongly chelating excess copper ions in the body to form soluble complexes that are excreted through the kidneys, effectively preventing the toxic accumulation of copper in organs. Similarly, based on this mechanism, it can also be used to treat certain heavy metal poisoning. When treating cystinuria, it can react with cysteine to form soluble disulfides, significantly reducing the risk of stone formation. In addition, as an immunomodulatory agent, D-penicillamine can improve the symptoms of rheumatoid arthritis by affecting T cell function and reducing rheumatoid factor levels.
Beyond its direct therapeutic use, D-Pen-OH's position in cutting-edge drug development is increasingly prominent. The thiol group (- SH) and chiral center in its molecule make it an ideal module for constructing complex bioactive molecules. A prominent example is that it serves as an important synthetic intermediate for Johnson&Johnson's development of IL-23 receptor oral cyclic peptide inhibitors. In the design of this type of innovative drug, the structure of D-penicillamine is integrated into the cyclic peptide skeleton, and its unique spatial conformation and reactivity play a crucial role in achieving high target affinity, excellent metabolic stability, and oral bioavailability of the drug.

 

 

 

    

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