Fmoc-D-Orn(Boc)-OH CAS 118476-89-4

The TNN Development Limited is one of the most reliable manufacturers and suppliers of fmoc-d-orn(boc)-oh cas 118476-89-4 in China. Please feel free to wholesale customized fmoc-d-orn(boc)-oh cas 118476-89-4 at low price from our factory. If you have any enquiry about free sample and discount information, please feel free to email us.

 

 

 

 

 

Fmoc-D-Orn (Boc) - OH (CAS: 118476-89-4) is a D-configured non natural amino acid derivative with orthogonal protection strategy, which serves as a key tool for achieving structural innovation and fine functional regulation in modern peptide drug development. Its molecular design combines the chiral center of D-ornithine, Fmoc protected alpha amino group, and Boc protected side chain amino group, providing a highly modular chemical platform for the synthesis of peptides with enhanced stability and novel biological activity.
The core advantage of this compound lies in its precise and controllable stepwise deprotection mechanism and unique D-configuration characteristics. Fmoc and Boc protecting groups form a classic orthogonal protection combination: Fmoc groups can be cyclically removed under mild alkaline conditions for efficient peptide chain elongation; The Boc group remains stable in subsequent steps and is selectively removed under strong acidic conditions, exposing the side chain primary amino group. This feature allows researchers to specifically functionalize the side chain amino groups during the late stage or completion of peptide synthesis, such as linking reporter groups, small molecule drugs, or constructing cyclic structures. At the same time, the introduced D-configured ornithine can effectively resist the recognition and cleavage of endogenous proteases, greatly improving the metabolic stability and in vivo half-life of peptides, overcoming the main limitations of traditional L-type peptide drugs.
Based on these characteristics, the intermediate has demonstrated significant application value in multiple cutting-edge fields. It is an essential building block for constructing specific peptide sequences containing non natural amino acids, such as antimicrobial peptides, enzyme inhibitors, or receptor ligands with optimized performance. Especially in the development of therapeutic peptides with complex structures and diverse functions, including cyclic peptides, dendritic peptides, and multivalent conjugates, the precise and programmable chemical modification sites provided by them open the door for medicinal chemists to explore new structure-activity relationships and mechanisms of action, and are key chemical entities driving the development of next-generation peptide therapies and chemical biology tools.

 

 

 

    

pack in 1kg/bag 10kg/bucket 20kg/bucket

 

 

 

 

 

 

Hot Tags: fmoc-d-orn(boc)-oh cas 118476-89-4, China, suppliers, manufacturers, factory, customized, wholesale, cheap, discount, low price, free sample, blood cholesterol meter, cholesterol strips, cholesterol test machine, Menthol crystal Refrigerated Container, Pharmaceutical Raw Materials, Top quality fast delivery Menthol