Fmoc-AEEA-OH CAS 166108-71-0

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Fmoc AEEA-OH is an extremely important and widely used advanced pharmaceutical intermediate, whose core value lies in the ability to introduce a flexible, hydrophilic polyethylene glycol (PEG like) segment into the target molecule. This characteristic makes it play an indispensable role in multiple cutting-edge pharmaceutical fields.
It is the core starting material for the long-acting technology of peptide drugs. In the synthesis process of Semaglutide, Retarutide, and various long-acting growth hormones, Fmoc AEEA-OH is used as a key building block for constructing fatty acid modified side chains. It serves as a hydrophilic spacer arm, with one end connected to a drug active peptide and the other end covalently bound to a fatty acid chain. This structure can significantly prolong the half-life of drugs, mainly by promoting reversible binding between drugs and albumin in the blood, and improving the solubility of molecules, thereby achieving a weekly or even longer dosing frequency, greatly improving patient medication compliance.
As a key intermediate in the synthesis of the fourth generation anti HIV drug Albuvirtide. In this application, Fmoc AEEA-OH is used for chemical modification of peptide chains derived from gp41. The introduction of AEEA structure not only enhances the metabolic stability of peptides, prolongs their antiviral (including HIV and SIV) action time, supports their long-term treatment regimen, but also helps maintain their efficient anti fusion activity.
The application of Fmoc AEEA-OH has surpassed traditional peptide drugs and extended to cutting-edge fields such as bio coupled drugs. It plays an important role as a degradable PEG linker in the synthesis of antibody drug conjugates (ADCs) and protein degradation targeted chimeras (PROTACs). Its dual functional group properties can efficiently connect different molecules such as antibodies, cell toxins, ligands, or target proteins for precise drug delivery and targeted therapy. Its good hydrophilicity and biocompatibility help improve the pharmacokinetic properties of coupled drugs, while its degradable design ensures that the drug can effectively release the payload and exert therapeutic effects after reaching the target site.

 

 

 

    

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