Boc-L-cyclopropylglycine CAS 152548-66-8

Product Name:Boc-L-cyclopropylglycine
CAS NO.:152548-66-8
Appearance:White powder
Other Name：Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester
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Description

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Products Description

Product name	Boc-L-cyclopropylglycine
CAS NO.	152548-66-8
Purity	＞98%
Alcohol	without alcohol
Packaging Type	PP bag/cardboard bucket
Material	pharmaceutical intermediates
Sheet Size	1kg/10kg/20kg
Prodcut Weight	1.2kg/12kg/23kg
Counts	1kg/bag 10kg/bucket 20kg/bucket
Certifications	ISO9001
Shelf life	24 month
MOQ	100 g

Functions

Fmoc-N-Me-Asp (OtBu) - OH (CAS: 152548-66-8) is a carefully designed advanced amino acid block with dual protection strategies, playing a key role in modern peptide pharmaceutical chemistry. Its molecular structure integrates both N-methylated main chain modification and tert butyl protection of side chain carboxyl groups, making it a core tool for synthesizing peptide drugs with excellent metabolic stability and precise structure.
The core value of this compound lies in its synergistic enhancement and precise control of peptide properties. N-Methylation modification can significantly enhance the resistance of peptides to protease degradation and improve their membrane permeability by reducing the hydrogen bond donor ability of amide bonds. This is crucial for the development of orally bioavailable peptide therapies. Meanwhile, the tert butyl ester protection of the side chain carboxyl group (OtBu) ensures that unnecessary side reactions do not occur in the Fmoc solid-phase synthesis strategy, thereby achieving precise introduction and subsequent selective deprotection of aspartic acid residues.
At the level of synthetic applications, this intermediate demonstrates excellent compatibility and multifunctionality. As a key structural unit, it enables medicinal chemists to introduce structurally restricted N-methylaspartic acid at specific sites on polypeptide chains, thereby systematically studying and optimizing the conformation, activity, and pharmacokinetic properties of peptides. This is not limited to the development of traditional peptide drugs, but also extends to the construction of cyclic peptides, peptide like compounds, and multifunctional biological conjugates.
Therefore, Fmoc-N-Me-Asp (OtBu) - OH surpasses the function of ordinary protected amino acids. It is an empowering tool that drives the development of next-generation peptide drugs, especially for therapies targeting difficult to drug targets that require crossing biological barriers. By precisely controlling the rigidity and stability of peptide chains at the molecular level, it provides a solid chemical foundation for the design of innovative drugs.