Fmoc-N-Me-Arg(pbf)-OH CAS 913733-27-4

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Fmoc-N-Me-Arg (Pbf) - OH (CAS: 913733-27-4) is a highly functionalized higher-order arginine derivative that serves as a key synthetic module for precise structural regulation in modern peptide pharmaceutical chemistry. Its molecular structure integrates Fmoc protected α - amino, N-methylated modified main chain, and Pbf protected guanidine, making it a core tool for constructing innovative peptide drugs with enhanced metabolic stability and specific biological activity.
The core value of this compound lies in its synergistic enhancement effect on peptide structure. N-methylation modification significantly enhances the resistance of peptides to protease degradation by reducing the hydrogen bond donor ability of amide bonds, while improving their membrane permeability, which is crucial for the development of oral peptide drugs. The complete guanidine structure, after deprotection, can provide critical cation - π interactions and hydrogen bond recognition capabilities, ensuring that peptides maintain high-intensity and highly selective binding with target proteins such as kinases or receptors.
At the level of synthetic chemistry, the molecule exhibits excellent orthogonal protection compatibility. The Fmoc protecting group can be gently removed under standard alkaline conditions, making it suitable for cyclic extension in solid-phase peptide synthesis; The Pbf protecting group is selectively removed under acidic conditions to ensure the stability of the guanidine functional group during the synthesis process. This characteristic enables researchers to accurately embed modified arginine residues into specific positions on the polypeptide chain, providing the possibility for systematic study of structure-activity relationships.
Based on these characteristics, Fmoc-N-Me-Arg (Pbf) - OH has broad application prospects in the field of biomedicine. It is not only an important structural unit for developing novel therapeutic peptides (especially candidate drugs that require enhanced stability and oral bioavailability), but also a chemical probe for studying the role of arginine in protein ligand interactions, providing a unique molecular tool for drug design and chemical biology research.

 

 

 

    

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