Fmoc-AzaTrp-OH CAS 737007-45-3

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Fmoc-AzaTrp-OH(FMOC-L-7-AZATRP) CAS: 737007-45-3 is an advanced structural unit with unique value in innovative drug chemistry and peptide research. Its molecular structure ingeniously combines the classic Fmoc-protected amino group, an alanine backbone, and a non-natural azapyrrolopyridine ring, marking it as a meticulously designed tryptophan analog specifically engineered to impart novel physicochemical and biological properties to peptides and proteins.
The core value of this compound lies in the indole ring with nitrogen in its structure. This key modification replaces a carbon atom in the indole ring of natural tryptophan with a nitrogen atom, significantly altering the electron distribution, hydrogen bonding capability, and metabolic stability of the heterocycle. As a synthetic intermediate, it provides researchers with a precise tool to directly embed this enhanced heterocyclic system into specific positions of polypeptide chains, enabling systematic study or optimization of the biological activity of target molecules.
In the field of biochemical research, Fmoc-AzaTrp-OH demonstrates broad application prospects. It is primarily used to construct novel peptides or peptidomimetics with enhanced properties. By introducing this unnatural amino acid, it can effectively: improve the metabolic stability of peptides and resist enzymatic degradation; fine-tune the interaction between peptides and target proteins (such as receptors or enzymes), enhancing their affinity and selectivity; and serve as a backbone for fluorescent probes, enabling the labeling and tracking of biomolecules. Therefore, Fmoc-AzaTrp-OH is not only a powerful tool for fundamental research but also a key chemical building block in advancing peptide-based lead compounds toward more stable and efficient candidate drugs.

 

 

 

 

    

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