Fmoc-Ser(HPO3Bzl)-OH CAS 158171-14-3

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Fmoc Ser (HPO3Bzl) - OH(Fmoc-O-(benzylphospho)-L-serine) CAS: 158171-14-3 is a strategically significant specific synthetic block for life science research and innovative drug discovery. Its molecular structure protects the α - amino group of serine with Fmoc groups, while the side chain hydroxyl group introduces phosphate groups in a stable benzyl ester form. This ingenious design makes it a powerful chemical tool for studying the key biological process of reversible protein phosphorylation.
The core value of this compound lies in its ability to accurately simulate the phosphorylation state of serine. In solid-phase peptide synthesis, researchers can use this intermediate to selectively insert phosphoserine into specific positions of the polypeptide chain, thereby synthesizing structurally determined phosphorylated peptides. These peptides, as key chemical probes, are mainly used in basic scientific research to explore the core mechanisms of serine phosphorylation in cell signal transduction, enzyme activity regulation, and metabolic pathways.
In the field of drug development, the application of Fmoc Ser (HPO3Bzl) - OH is particularly critical. It is widely used in the design and synthesis of novel drug molecules targeting phosphorylation related targets such as kinases and phosphatases. By integrating phosphate amino acid analogues into candidate compounds, it is possible to effectively simulate the transition state of substrates or inhibitors, thereby developing highly active and selective therapeutic drugs, which are indispensable in drug design for tumors, metabolic diseases, and neurological disorders.
In addition, this compound also plays an important role in analytical science, often used as a standard or reference substance for the development and validation of analytical detection methods for phosphorylated proteins and peptides. Its benzyl protecting group can be selectively removed in the later stage of synthesis, providing flexible chemical operability for constructing more complex phosphorylated biomolecules, fully demonstrating its bridging role between basic research and industrial applications.

 

 

 

 

    

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