(NMe)G-RVYIHPT|53632-49-8

Specific angiotensin II competitive antagonist.
Product Name: Octapeptide (NMe)G-RVYIHPT
CAS No.: 53632-49-8
Single-letter code: H2N-(NMe)G-RVYIHPT-OH
Number of amino acids: 8
Molecular formula: C44H69N13O11
Average molecular weight: 956.1
Source: Artificial chemical synthesis, for scientific research purposes only, not for human use.
Storage conditions: -80°C to -20°C

Methylated modified peptide
Also known as methylated labeled peptides, methylation modification is a type of post-translational modification (PTMs) of proteins that participates in almost all cellular life processes and plays an important regulatory role. Proteins covalently bind methyl groups to specific amino acid residues under the catalysis of methyltransferases. Methylation is a reversible modification process catalyzed by demethylases.
Research has found that the common amino acids involved in methylation/demethylation are lysine (Lys) and arginine (Arg). Studies have shown that histone lysine methylation modifications perform various biological functions, such as maintaining and differentiating stem cells, X chromosome inactivation, transcriptional regulation, and DNA damage response, mainly affecting chromatin condensation and inhibiting gene expression. Histone arginine methylation plays an important role in gene transcription regulation and can affect various physiological processes in cells, including DNA repair, signal transduction, cell development, and cancer occurrence. Therefore, Peptide Biotech has specifically developed methylation modified peptide technology to assist scientists in the study of post-translational modifications (PTMS) of proteins.

Methylation modification (Me1, Me2, Me3)
Adopting high-quality Fmoc-Lys(Me,Boc)-OH, Fmoc-Lys(Me2)-OH,Fmoc-Lys(Me3)-OH.HCL,Fmoc-Arg(Me,Pbf)-OH ,Fmoc-Arg(me)2-OH.HCl(asymmetrical) ,Fmoc-Arg(me)2-OH.HCl(symmetrical) Using Fmoc solid-phase synthesis process, peptides labeled with Lys methylation and Arg methylation were synthesized from the raw materials, and the products were purified by HPLC. The final product provides corresponding mass spectra and HPLC chromatograms for purity analysis.