AEEA-AEEA CAS 1143516-05-5

The CAS number is the only "identification card" for chemical substances worldwide, and a complete supplier network and regulatory compliance traceability system have been formed around CAS 1143516-05-5. Understanding this system is crucial for procurement, import, and drug declaration.
Global supplier landscape: The main suppliers are distributed in North America, Europe, and Asia. North America: Sigma Aldrich (MilliporeSigma) offers research grade (purity>95%) and GMP grade products, packaged from 100 mg to 1 kg. Europe: Iris Biotech GmbH (Germany) and Bachem (Switzerland) specialize in Fmoc-AEEA-AEEA-OH for peptide synthesis, with purity>98%. Asia: China's Meryer, Aladdin, Bide Pharm, and others offer cost-effective products at prices approximately one-third to one-half of those in Europe and America; Wako and TCI from Japan also supply. All suppliers provide COA, including HPLC purity, moisture (KF), residual solvents, and IR/NMR/MS spectra.
Compliance traceability: ① REACH regulation (EU): Registration must be completed for exports to the EU, and complete registration files must be submitted for annual production of ≥ 1 ton. Most suppliers have obtained REACH registration numbers. ② TSCA (USA): CAS 1143516-05-5 is included in the TSCA list, and imports require PMN or SNUR declaration, but it is usually exempted as an intermediate. ③ Registration of Chinese CDE original and auxiliary packages: AEEA-AEEA used for ADC or GLP-1 drug production must be registered on the CDE original and auxiliary package platform, obtain a registration number (such as Y2025-xxxxx), and pass the relevant review before it can be used for formulation. ④ DMF file: Some suppliers hold DMF (Class II) from the US FDA and authorize customers to cite it to support IND/NDA declarations. DMF authorization letter and stability data should be requested during procurement. Traceability systems such as blockchain traceability (adopted by some suppliers) can query the production, purification, packaging, and testing records of each batch.