Pharmacology and toxicology of dihydroartemisinin tablets

Pharmacology: This product is a derivative of artemisinin, which has strong and rapid killing effect on Plasmodium erythrocytic phase, and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is not very clear, which mainly interferes with the function of Plasmodium surface membrane mitochondria. Artemisinin changes the membrane structure of Plasmodium by affecting the ultrastructure of its erythrocytic phase. Because of its effect on food vesicles, the nutrient uptake of Plasmodium is blocked, resulting in the loss of a large number of Plasmodium cytoplasm and nutrients, and the lack of supplement, resulting in the rapid death of Plasmodium. The mechanism of action is mediated by the free iron produced by the decomposition of hemoglobin through its internal peroxide (dioxygen) bridge, which produces unstable organic free radicals and / or other electrophilic mediators, and then forms covalent adducts with the proteins of Plasmodium, resulting in the death of Plasmodium. The antimalarial activity of artemether was 6 times higher than that of artemisinin. Toxicology: Studies on animal reproductive toxicity have proved that administration during induction period of pregnancy in mice can increase embryo absorption, but has no teratogenic effect.