Fmoc-Aib-OH CAS 94744-50-0

Product Name:Fmoc-Aib-OH
CAS NO.:94744-50-0
Appearance:White powder
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Description

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Products Description

Product name	Fmoc-Aib-OH
CAS NO.	94744-50-0
Purity	＞98%
Alcohol	without alcohol
Packaging Type	PP bag/cardboard bucket
Material	pharmaceutical intermediates
Sheet Size	1kg/10kg/20kg
Prodcut Weight	1.2kg/12kg/23kg
Counts	1kg/bag 10kg/bucket 20kg/bucket
Certifications	ISO9001
Shelf life	24 month
MOQ	100 g

Functions

Fmoc Ab OH (CAS: 94744-50-0) is an advanced synthetic block with unique conformational constraint function in peptide engineering. The alpha carbon atom in its molecular structure is replaced by two methyl groups, forming a unique alpha, alpha dialkyl non natural amino acid skeleton. This feature makes it a key tool for regulating the three-dimensional structure and physicochemical properties of peptide chains, demonstrating irreplaceable value in drug design and materials science.
The core function of this compound stems from its strong conformational restriction ability. Compared with natural amino acids, Aib residues can significantly limit the rotational degrees of freedom of the main chain's π and π dihedral angles, strongly inducing the formation of stable 310 or α - helix structures in peptide chains. This pre organized structure not only enhances the metabolic stability of peptides for protease degradation, but also precisely locks their bioactive conformation, thereby significantly improving the binding affinity and specificity with target proteins. Meanwhile, it completely lacks the characteristic of chemically reactive side chains, completely avoiding possible side reactions during the synthesis process and ensuring the synthesis efficiency and purity of the target peptide compound.
In the field of innovative drug development, Fmoc Ab OH has become a strategic resource for optimizing the performance of therapeutic peptides. By accurately embedding it into peptide sequences, medicinal chemists can systematically regulate the secondary structure of candidate compounds, enhance membrane permeability, and prolong in vivo half-life, which is crucial for the development of oral peptide drugs and long-acting formulations. In addition, this structural unit also performs well in constructing self-assembled peptide nanomaterials. Its introduction can guide peptide molecules to form regular supramolecular structures, providing a novel molecular design platform for the development of drug delivery systems and tissue engineering scaffolds.